Assistant professor Dina Petranovic, PhD Department of Chemical and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE-412 96 Göteborg, Sweden Phone: +46(0)31 772 3836 Fax: +46(0)31 772 3801 E-mail: dina.petranovic [at] chalmers.se Office: Room 3055A         Education and degrees 1999 M.Sc. in Molecular Biology, Faculty of Science and Mathematics, University of Zagreb, Croatia 2004 Ph.D. in Molecular Microbiology, University Paris XI, France Employments 1997-1998 Teaching Assistant and Researcher, Faculty of Science and Mathematics, University of Zagreb, Croatia 2000-2004 PhD student, University Paris XI and INRA, Paris, France 2004-2007 Assistant Professor, Molecular Physiology and Genetics, Technical University of Denmark, Lyngby, Denmark 2007-2008 Project Manager, Center for Microbial Biotechnology, Technical University of Denmark, Lyngby, Denmark 2008- Assistant Professor, Department of Chemical and Biological Engineering, Chalmers Academic Experience 2004- Reviewer for several international peer-reviewed scientific journals 2009 & 2010 Expert for evaluation of proposals for the French National Research Agency (ANR) 2010 Reviewer for South African Funding Agency Publications 2001 Petranović M, Zahradka K, Zahradka D, Petranović D, Nagy B, Salaj-Smic E, Petranović D. Genetic evidence that the elevated levels of Escherichia coli helicase II antagonize recombinational DNA repair. Biochimie. 83:1041-7 2004 Petranovic D, Mijakovic I. Photometric assay for measuring the intracellular concentration of branched-chain amino acids in bacteria. J Microbiol Methods. 01:133-6   Petranovic D, Guédon E, Sperandio B, Delorme C, Ehrlich D, Renault P. Intracellular effectors regulating the activity of the Lactococcus lactis CodY pleiotropic transcription regulator. Mol Microbiol. 2:613-21   Mijakovic I, Petranovic D, Deutscher J. How tyrosine phosphorylation affects the UDP-glucose dehydrogenase activity of Bacillus subtilis YwqF. J Mol Microbiol Biotechnol. 1:19-25 2005 Mijakovic I, Musumeci L, Tautz L, Petranovic D, Edwards RA, Jensen PR, Mustelin T, Deutscher J, Bottini N. In vitro characterization of the Bacillus subtilis protein tyrosine phosphatase YwqE. J Bacteriol. 10:3384-90   Mijakovic I, Petranovic D, Jensen PR. Tunable promoters in systems biology. Curr Opin Biotechnol. 3:329-35   Mijakovic I, Petranovic D, Bottini N, Deutscher J, Ruhdal Jensen P. Protein-tyrosine phosphorylation in Bacillus subtilis. J Mol Microbiol Biotechnol. 9 (3-4):189-97 2006 Mijakovic I, Petranovic D, Macek B, Cepo T, Mann M, Davies J, Jensen PR, Vujaklija D. Bacterial single-stranded DNA-binding proteins are phosphorylated on tyrosine. Nucleic Acids Res. 5:1588-96 2007 Petranovic D, Michelsen O, Zahradka K, Silva C, Petranovic M, Jensen PR, Mijakovic I. Bacillus subtilis strain deficient for the protein-tyrosine kinase PtkA exhibits impaired DNA replication. Mol Microbiol. 6:1797-805 2008 Koebmann B, Blank LM, Solem C, Petranovic D, Nielsen LK, Jensen PR. Increased biomass yield of Lactococcus lactis during energetically limited growth and respiratory conditions Biotechnol Appl Biochem. 50(Pt 1):25-33   Soufi B, Jers C, Hansen ME, Petranovic D, Mijakovic I. Insights from site-specific phosphoproteomics in bacteria. Biochim Biophys Acta. 1:186-92   Soufi B, Gnad F, Jensen PR, Petranovic D, Mann M, Mijakovic I, Macek B. The Ser/Thr/Tyr phosphoproteome of Lactococcus lactis IL1403 reveals multiply phosphorylated proteins. Proteomics. 17:3486-93   Petranovic D, Nielsen J. Can yeast systems biology contribute to the understanding of human disease? Trends Biotechnol. 11:584-90   Herrgård MJ, Swainston N, Dobson P, Dunn WB, Arga KY, Arvas M, Blüthgen N, Borger S, Costenoble R, Heinemann M, Hucka M, Le Novère N, Li P, Liebermeister W, Mo ML, Oliveira AP, Petranovic D, Pettifer S, Simeonidis E, Smallbone K, Spasić I, Weichart D, Brent R, Broomhead DS, Westerhoff HV, Kirdar B, Penttilä M, Klipp E, Palsson BØ, Sauer U, Oliver SG, Mendes P, Nielsen J, Kell DB. A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology. Nat Biotechnol. 10:1155-60 2009 Petranovic D, Grangeasse C, Macek B, Abdillatef M, Gueguen-Chaignon V, Nessler S, Deutscher J, Mijakovic I. Activation of Bacillus subtilis Ugd by the BY-Kinase PtkA Proceeds via Phosphorylation of Its Residue Tyrosine 70. J Mol Microbiol Biotechnol. 17(2):83-9.   Petranovic D & Vemuri GN Impact of yeast systems biology on industrial biotechnology. J Biotechnol. 144(3):204-11. 2010 Solem C, Petranovic D, Koebmann B, Mijakovic I, Jensen PR (2010) Phosphoglycerate Mutase Is a Highly Efficient Enzyme without Flux Control in Lactococcus lactis. J Mol Microbiol Biotechnol. 18:174–180   Petranovic D, Tyo K, Vemuri GN, Nielsen J (2010) Prospects of yeast systems biology for human health: integrating lipid, protein and energy metabolism. FEMS Yeast Res. Dec;10(8):1046-59   Canelas A. B, Harrison N, Fazio A, Zhang J, Pitkänen J-P, van den Brink J, Bakker B.M., Bogner L, Bouwman J, Castrillo J.I, Cankorur A, Chumnanpuen P, Daran-Lapujade P, Dikicioglu D, van Eunen K, Ewald J. C, Heijnen J. J, Kirdar B, Mattila I, Mensonides F. I. C, Niebel A, Penttilä M, Pronk J. T., Reuss M, Salusjärvi L, Sauer U, Sherman D, Siemann-Herzberg M, Westerhoff H, de Winde J, Petranovic D, Oliver S. G, Workman C. T, Zamboni N, Nielsen J (2010) Integrated multi-laboratory systems biology reveals 1 differences in protein metabolism between two reference 2 yeast strains. Nature Comm., 1:145. doi: 10.1038/ncomms1150 2011 Ruenwai R, Neiss A, Laoteng K, Vongsangnak W, Badoei Dalfard A, Cheevadhanarak S. Petranovic D, Nielsen J. (2011) PUFAs in yeast cause a global stress response due to reduced proteasomal activity and increased oxidative stress. J. of Biotechnol. 6(3):343-56. doi: 10.1002/biot.201000316   Karlsson FH, Nookaew I, Petranovic D, Nielsen J. (2011) Prospects for systems biology and modeling of the gut microbiome. Trends Biotechnol. 29:251-258   Liu Z, Tyo KE, Martínez JL, Petranovic D, Nielsen J. (2011) Different expression systems for production of recombinant proteins in Saccharomyces cerevisiae. Biotechnol. Bioeng., doi: 10.1002/bit.24409. [Epub ahead of print]   Munoz AJ, Wanichthanarak K, Meza E, Petranovic D. (2011) Systems Biology of Yeast Cell Death. FEMS Yeast Res. doi: 10.1111/j.1567-1364.2011.00781.x. [Epub ahead of print] 2012 Jin Hou, Keith Tyo; Zihe Liu; Dina Petranovic; Jens  Nielsen. Engineering of Vesicle Trafficking Improves Heterologous Protein Secretion in Saccharomyces cerevisiae. Metabolic Engineering in press Teaching and Tutoring Experience 1997-1998 Biochemistry, University of Zagreb, Croatia 2004-2007 Molecular Genetics course, Technical University of Denmark 2004-2007 Molecular Biotechnology course, Technical University of Denmark Since 2010 Introduction to Molecular and Cell Biology (also examiner), Chalmers University, Sweden Since 2011 Molecular and Cell Biology 2 (also examiner), Chalmers University, Sweden Since 2004 Supervised until now 2 technicians, 4 M.Sc. students and 3 post-docs. Currently supervising 3 BSc students, 3 PhD students and 1 post-doc and co-supervising additionally 3 post-docs and 4 PhD students. Grants, Awards and Prizes 2000-2001 Award and Scholarship from the French Goverment 2001-2004 INRA PhD Scholarship, France 2009 Wallenberg Foundation Travel Grant 2011-2014 Chalmers Faculty Fund Organization and Management 2007-2009 Project manager for “Yeast Systems Biology Network” YSBN (EU-funded project in the 6th framework, over 20 partner labs) 2007-2010 Project manager for “NordForsk network” (a Nordic network, 10 partner labs) 2008-2011 Project manager for “Systems Biology as a Driver for Industrial Biotechnology” SYSINBIO (EU-funded projects in the 7th framework, over 20 partner labs). 2008 Organizing committee of the International Conference for Systems Biology ICSB2008 (Gothenburg, Sweden) 2009 Expert for evaluation of proposals for the French National Research Agency 2010 Expert for evaluation of proposals for the French National Research Agency 2010- Project manager of “NordSysBio” (Nordic network for systems biology of metabolism, 9 partner labs) 2010 Reviewer for the South African Funding Agency 2010 Organizing committee and chair at the Conference on Systems Biology of Microorganisms (Paris, France)   Organizing committee and chair at the Industrial Systems Biology (Gothenburg Life Science Conference XI)   Poster evaluation judge at PYFF4, Rotterdam 2011 Expert for evaluation of proposals for LABEX (Laboratoires d’Excellence), French Governmental program for Scientific Excellence Personal text I am coming from the background of molecular microbiology and have been working mainly on gene regulation (CodY) and protein phosphorylation (PY) in G+ bacteria (Lactococcus lactis, Bacillus subtilis). In the last few years I became interested in using unicellular Eukarya such as yeast Saccharomyces cerevisiae as a model organism for study of complex cellular functions, such as proteome maintenance, ageing and apoptosis.