Our research focus is on systems biology of metabolism. The yeast Saccharomyces cerevisiae is our key model organism, but we also have research on Aspergilli (experimental and theoretical) and on mammalian cells (theoretical). Our research activities fall in three areas:
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Studying regulatory pathways that are conserved in the Eukaryal kingdom such as the Snf1/AMPK pathway, the Tor1 pathway, protein folding, secretion and degradation, and apoptosis. We also study the regulation of lipid biosynthesis and metabolism.
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Developing metabolic models for Eukaryal cells, including rodent and human cells and using these models as scaffolds for analysis of omics data with the objective to understand global responses to nutrients and disease. Experimental work is carried in collaboration with other research groups.
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Developing efficient cell factories (yeast and Aspergilli) for sustainable production of chemicals. We are looking into both the production of high-value chemicals such as isoprenoids, polyketides and non-ribosomal peptides, and commodity chemicals that can be used as sustainable feedstocks in the chemical industry.
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